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pentobarbital will lessen the extent or impact of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will lessen the extent or effect of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Labor and delivery: Hypnotic doses of such barbiturates tend not to